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Table 2 Changes of BMD in L4-L6 vertebrae in different treatment groups over time

From: Alendronate (ALN) combined with Osteoprotegerin (OPG) significantly improves mechanical properties of long bone than the single use of ALN or OPG in the ovariectomized rats

Groups L4-L6 Vertebrae Mean BMD (g/cm2)
  Before OVX 12 weeks post-OVX 24 weeks post-OVX
Sham 0.21 ± 0.046 0.34 ± 0.023 0.37 ± 0.017
OVX 0.22 ± 0.039 0.27 ± 0.039 0.27 ± 0.022a
OVX+ALN 0.21 ± 0.043 0.27 ± 0.039 0.37 ± 0.029
OVX+OPG-Fc 0.19 ± 0.038 0.23 ± 0.025 0.38 ± 0.026
OVX+ALN+OPG-Fc 0.19 ± 0.034 0.27 ± 0.020 0.36 ± 0.027
  1. (a): Group had significantly lower value than that of all the other groups at the given time, p < 0.05.