Figure 3

At 24 weeks post OVX (12 weeks following treatment), serum osteocalcin level decreased by 23% to the baseline level (sham group) in the ALN-treated group; 35% to the baseline level in the OPG-Fc-treated group; and 58% to the baseline level in the OPG+ALN-treated group, which was significantly reduced (#p < 0.05, Student's t-test) comparing to the sham group. There was no statistical difference among the three treatment groups.