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Figure 2 | Journal of Orthopaedic Surgery and Research

Figure 2

From: Alendronate (ALN) combined with Osteoprotegerin (OPG) significantly improves mechanical properties of long bone than the single use of ALN or OPG in the ovariectomized rats

Figure 2

Western blot analysis showed the RANKL protein expression in the vertebral bones at 12 weeks after receiving different treatments (24 weeks post-OVX). RANKL protein expression in the vertebrae was significantly increased in the OVX group compared to all other groups. If we use the RANKL protein expression in the OVX group as baseline level of 100%, the OPG-Fc treatment reduced the RANKL protein expression to 60% of baseline level; ALN treatment further reduced the RANKL protein expression to 40% of the baseline level; the RANKL protein expression in the OPG-Fc+ALN treated group and the sham control group was similar and was lowest among the groups, only 20% of the OVX group baseline level. *p < 0.05 when compared to the OVX group and there was no statistical difference among the tree treatment groups.

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