Table 3 Histological Grading Scores
From: Augmentation of osteochondral repair with hyperbaric oxygenation: a rabbit study
Time | Group (N = 4)* | Filling of Defect (Category 1) | Cellular Morphology (Category 2) | Surface Architecture (Category 3) | Matrix Staining (Category 4) | Tidemark (Category 5) | Integration (Category 6) | Subchondral Bone (Category 7) | Total Score | p Value†|
|---|---|---|---|---|---|---|---|---|---|---|
2 weeks | C | 1.5 ± 0.6 | 2.0 ± 0.0 | 1.8 ± 0.5 | 2.0 ± 0.0 | 2.3 ± 0.5 | 2.0 ± 0.0 | 2.0 ± 0.8 | 11.5 ± 1.3 | 0.021 |
|  | F | 1.3 ± 0.5 | 1.5 ± 0.6 | 2.0 ± 0.0 | 1.0 ± 0.0 | 1.5 ± 0.6 | 1.3 ± 0.5 | 1.0 ± 0.0 | 8.5 ± 1.7 | 0.076 |
|  | H | 0.8 ± 0.5 | 1.0 ± 0.8 | 1.3 ± 0.5 | 0.8 ± 0.5 | 1.3 ± 0.5 | 1.0 ± 0.0 | 1.5 ± 0.6 | 6.0 ± 2.1 | 0.655 |
|  | H+F | 0.3 ± 0.5 | 1.0 ± 0.8 | 1.3 ± 0.5 | 1.0 ± 0.0 | 1.3 ± 0.5 | 1.0 ± 0.0 | 1.0 ± 0.8 | 5.8 ± 1.7 |  |
4 weeks | C | 0.5 ± 0.6 | 1.5 ± 1.3 | 1.5 ± 0.6 | 1.8 ± 0.5 | 1.5 ± 0.6 | 1.5 ± 0.6 | 1.8 ± 0.5 | 8.3 ± 3.5 | p = 0.353‡ |
|  | F | 0.5 ± 0.6 | 0.8 ± 1.0 | 1.0 ± 0.0 | 1.5 ± 0.6 | 1.0 ± 0.0 | 1.0 ± 0.0 | 0.5 ± 0.6 | 5.8 ± 2.1 |  |
|  | H | 0.0 ± 0.0 | 1.0 ± 0.0 | 0.8 ± 0.5 | 1.0 ± 0.0 | 0.8 ± 0.5 | 1.0 ± 0.0 | 1.3 ± 0.5 | 4.8 ± 0.6 |  |
|  | H+F | 0.0 ± 0.0 | 1.0 ± 0.8 | 1.0 ± 0.0 | 1.0 ± 0.0 | 1.0 ± 0.0 | 1.0 ± 0.0 | 0.0 ± 0.0 | 5.0 ± 0.8 |  |
6 weeks | C | 0.5 ± 0.6 | 1.8 ± 0.5 | 2.0 ± 0.0 | 1.5 ± 0.6 | 2.5 ± 0.6 | 1.3 ± 0.5 | 2.0 ± 0.0 | 9.5 ± 1.3 | 0.014 |
|  | F | 0.5 ± 0.6 | 1.0 ± 0.8 | 1.3 ± 0.5 | 1.3 ± 0.5 | 1.3 ± 0.5 | 1.3 ± 0.5 | 1.5 ± 0.6 | 6.5 ± 3.1 | 0.014 |
|  | H | 0.0 ± 0.0 | 0.0 ± 0.0 | 1.0 ± 0.0 | 0.0 ± 0.0 | 1.0 ± 0.0 | 1.0 ± 0.0 | 0.8 ± 0.5 | 3.0 ± 0.0 | 1.000 |
|  | H+F | 0.0 ± 0.0 | 0.0 ± 0.0 | 1.0 ± 0.0 | 0.0 ± 0.0 | 1.0 ± 0.0 | 1.0 ± 0.0 | 0.5 ± 0.6 | 3.0 ± 0.0 |  |
8 weeks | C | 0.5 ± 0.6 | 1.8 ± 0.5 | 1.8 ± 0.5 | 1.5 ± 0.6 | 1.5 ± 0.6 | 1.0 ± 0.0 | 1.8 ± 0.5 | 7.5 ± 1.9 | 0.013 |
|  | F | 0.3 ± 0.5 | 1.0 ± 0.0 | 1.0 ± 0.0 | 1.0 ± 0.0 | 1.3 ± 0.5 | 0.8 ± 0.5 | 1.3 ± 0.5 | 5.3 ± 1.3 | 0.013 |
|  | H | 0.0 ± 0.0 | 0.3 ± 0.5 | 1.0 ± 0.0 | 0.0 ± 0.0 | 1.0 ± 0.0 | 1.0 ± 0.0 | 1.0 ± 0.0 | 3.3 ± 0.5 | 0.317 |
|  | H+F | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.8 ± 0.5 | 0.3 ± 0.5 | 1.0 ± 0.0 | 1.0 ± 0.0 | 1.0 ± 0.0 | 3.0 ± 0.0 |  |
12 weeks | C | 0.3 ± 0.5 | 1.3 ± 0.5 | 1.5 ± 0.6 | 1.3 ± 0.5 | 1.8 ± 0.5 | 1.3 ± 0.5 | 1.8 ± 0.5 | 7.3 ± 1.7 | 0.019 |
|  | F | 0.3 ± 0.5 | 1.0 ± 0.0 | 1.0 ± 0.0 | 0.5 ± 0.6 | 1.0 ± 0.0 | 1.0 ± 0.0 | 1.3 ± 0.5 | 4.8 ± 0.5 | 0.017 |
|  | H | 0.0 ± 0.0 | 0.3 ± 0.5 | 0.5 ± 0.6 | 0.3 ± 0.5 | 0.5 ± 0.6 | 0.3 ± 0.5 | 0.8 ± 0.5 | 1.8 ± 1.5 | 0.536 |
|  | H+F | 0.0 ± 0.0 | 0.8 ± 1.0 | 0.5 ± 0.6 | 0.0 ± 0.0 | 0.3 ± 0.5 | 0.3 ± 0.5 | 0.5 ± 0.6 | 1.8 ± 0.6 |  |