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Table 3 Histological Grading Scores

From: Augmentation of osteochondral repair with hyperbaric oxygenation: a rabbit study

Time Group
(N = 4)*
Filling of Defect
(Category 1)
Cellular Morphology (Category 2) Surface Architecture (Category 3) Matrix Staining
(Category 4)
Tidemark (Category 5) Integration (Category 6) Subchondral Bone (Category 7) Total Score p
Value
2 weeks C 1.5 ± 0.6 2.0 ± 0.0 1.8 ± 0.5 2.0 ± 0.0 2.3 ± 0.5 2.0 ± 0.0 2.0 ± 0.8 11.5 ± 1.3 0.021
  F 1.3 ± 0.5 1.5 ± 0.6 2.0 ± 0.0 1.0 ± 0.0 1.5 ± 0.6 1.3 ± 0.5 1.0 ± 0.0 8.5 ± 1.7 0.076
  H 0.8 ± 0.5 1.0 ± 0.8 1.3 ± 0.5 0.8 ± 0.5 1.3 ± 0.5 1.0 ± 0.0 1.5 ± 0.6 6.0 ± 2.1 0.655
  H+F 0.3 ± 0.5 1.0 ± 0.8 1.3 ± 0.5 1.0 ± 0.0 1.3 ± 0.5 1.0 ± 0.0 1.0 ± 0.8 5.8 ± 1.7  
4 weeks C 0.5 ± 0.6 1.5 ± 1.3 1.5 ± 0.6 1.8 ± 0.5 1.5 ± 0.6 1.5 ± 0.6 1.8 ± 0.5 8.3 ± 3.5 p = 0.353
  F 0.5 ± 0.6 0.8 ± 1.0 1.0 ± 0.0 1.5 ± 0.6 1.0 ± 0.0 1.0 ± 0.0 0.5 ± 0.6 5.8 ± 2.1  
  H 0.0 ± 0.0 1.0 ± 0.0 0.8 ± 0.5 1.0 ± 0.0 0.8 ± 0.5 1.0 ± 0.0 1.3 ± 0.5 4.8 ± 0.6  
  H+F 0.0 ± 0.0 1.0 ± 0.8 1.0 ± 0.0 1.0 ± 0.0 1.0 ± 0.0 1.0 ± 0.0 0.0 ± 0.0 5.0 ± 0.8  
6 weeks C 0.5 ± 0.6 1.8 ± 0.5 2.0 ± 0.0 1.5 ± 0.6 2.5 ± 0.6 1.3 ± 0.5 2.0 ± 0.0 9.5 ± 1.3 0.014
  F 0.5 ± 0.6 1.0 ± 0.8 1.3 ± 0.5 1.3 ± 0.5 1.3 ± 0.5 1.3 ± 0.5 1.5 ± 0.6 6.5 ± 3.1 0.014
  H 0.0 ± 0.0 0.0 ± 0.0 1.0 ± 0.0 0.0 ± 0.0 1.0 ± 0.0 1.0 ± 0.0 0.8 ± 0.5 3.0 ± 0.0 1.000
  H+F 0.0 ± 0.0 0.0 ± 0.0 1.0 ± 0.0 0.0 ± 0.0 1.0 ± 0.0 1.0 ± 0.0 0.5 ± 0.6 3.0 ± 0.0  
8 weeks C 0.5 ± 0.6 1.8 ± 0.5 1.8 ± 0.5 1.5 ± 0.6 1.5 ± 0.6 1.0 ± 0.0 1.8 ± 0.5 7.5 ± 1.9 0.013
  F 0.3 ± 0.5 1.0 ± 0.0 1.0 ± 0.0 1.0 ± 0.0 1.3 ± 0.5 0.8 ± 0.5 1.3 ± 0.5 5.3 ± 1.3 0.013
  H 0.0 ± 0.0 0.3 ± 0.5 1.0 ± 0.0 0.0 ± 0.0 1.0 ± 0.0 1.0 ± 0.0 1.0 ± 0.0 3.3 ± 0.5 0.317
  H+F 0.0 ± 0.0 0.0 ± 0.0 0.8 ± 0.5 0.3 ± 0.5 1.0 ± 0.0 1.0 ± 0.0 1.0 ± 0.0 3.0 ± 0.0  
12 weeks C 0.3 ± 0.5 1.3 ± 0.5 1.5 ± 0.6 1.3 ± 0.5 1.8 ± 0.5 1.3 ± 0.5 1.8 ± 0.5 7.3 ± 1.7 0.019
  F 0.3 ± 0.5 1.0 ± 0.0 1.0 ± 0.0 0.5 ± 0.6 1.0 ± 0.0 1.0 ± 0.0 1.3 ± 0.5 4.8 ± 0.5 0.017
  H 0.0 ± 0.0 0.3 ± 0.5 0.5 ± 0.6 0.3 ± 0.5 0.5 ± 0.6 0.3 ± 0.5 0.8 ± 0.5 1.8 ± 1.5 0.536
  H+F 0.0 ± 0.0 0.8 ± 1.0 0.5 ± 0.6 0.0 ± 0.0 0.3 ± 0.5 0.3 ± 0.5 0.5 ± 0.6 1.8 ± 0.6  
  1. *Group: C = control; F = fibrin; H = hyperbaric oxygen (HBO); H+F = HBO+fibrin; A p value of 0.05 or less on the Mann-Whitney rank sum test was considered statistically significant for selective comparisons between the H+F group and other groups; P value was 0.353 on the Kruskal-Wallis test, indicating that there was no significant difference between groups.