Figure2
From: Transcriptional regulation of bone formation by the osteoblast-specific transcription factor Osx
Model of mechanisms of the Osx inhibitory effect on Wnt pathway. Osx negatively controls Wnt pathway by two different mechanisms: activates the expression of Wnt antagonist Dkk1 and disrupts Tcf binding to DNA to inhibit the transcriptional activity of β-catenin/Tcf.