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Table 6 Study Characteristics of Selected Experimental Controlled Anima Studies on He-Ne Low Level Laser Irradiation Effects on Bone Healing

From: Effects of low power laser irradiation on bone healing in animals: a meta-analysis

Authors Laser Output
(mw)
Distance between Producer and Skin
(cm)
Irradiation Time per Day
(min)
Number of treatment sessions Irradiated energy per session Total Irradiated Energy
David et al., 1996 10 N/A N/A    2 week 4 week 6 week
     (2 week) 6 0 0 0 0
     (4 week) 13 2 12 26 40
     (6 week) 20 4
(J) every other day
24 52
(Joules)
80
Luger et al., 1998 35 20 **
30
14 *** ***   
      21 J (each area) 294 (J) (each area)
      63 J (in total) 882 (J) (in total)
Tajali et al., 2003 2 N/A **
30
14 1.2 (J/cm2) 16.8 (J/cm2) ***
     21   5.2 (J/cm2)
     28   33.6 (J/cm2)
Teng
et al.,
2006
N/A N/A 10 35 *** ***   
      He-Ne: 16.8 (J/cm2) He - Ne: 588 (J/cm2)
      Co2: 90 (J/cm2) Co2: 3150 (J/cm2)
  1. ** Including 10 minutes on fracture area, 10 minutes on the area above the point of fracture, and 10 minutes on the area below the fracture. *** Meta analysis authors calculated amount of irradiated energy based on the articles data with this equation [43]:
  2. Set Power (w) * Time (s) = Total Amount of Energy (J)
  3. Total Amount of Energy/Treatment Surface (cm2) = Energy Density (J/cm2)