Total BMC and BMD at the femoral neck measured by pQCT densitometry. Effects of alendronate (ALN), calcitriol (VitD), and combined alendronate and calcitriol treatments (ALN+VitD) on the pQCT densitometric parameters of total BMC and BMD at the femoral neck in OVX rats after 12 weeks of treatment are shown. The data are presented as mean ± SD (n = 6 per group). # P < 0.05, ### P < 0.001 as compared with corresponding values in saline-treated OVX (unpaired t-test). * P < 0.05, ** P < 0.01 as compared with corresponding values in saline-treated OVX (Tukey's multiple comparison test). Total BMC and BMD were significantly lower in the saline-treated OVX compared with the sham group. Alendronate treatment, with or without calcitriol, induced a significant improvement in both total BMC and BMD.