Macroscopic observation of in vitro constructs. Figure 2A represents PLGA scaffold which was designed in the shape of cylindrical disc. Fibrin/PLGA constructs (Figure 2B) and PLGA construct (Figure 2C) was morphologically similar after 7 days in culture. Fibrin/PLGA construct (Figure 2D) showed slightly smooth and glistening morphology when compared to PLGA (Figure 2E) after 14 days. By week 3, fibrin/PLGA construct appeared whiter, smoother and glistening (Figure 2F) than PLGA (Figure 2G).