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Table 3 Differentially expressed genes in the ACL-X knee by region in the tibial plateau

From: Site-specific analysis of gene expression in early osteoarthritis using the Pond-Nuki model in dogs

p value ACL-X Control CrMTP CrLTP ACL-X Control p value
<0.05 0.093 ± 0.02 0.018 ± 0.018 MMP 13 COL 1 5.46 ± 3.96 0.48 ± 0.08 <0.05
     COL 2 1022 ± 651 254 ± 84 <0.05
     MMP 13 0.147 ± 0.012 0 ± 0 <0.05
     INOS 0.362 ± 0.065 0.04 ± 0.04 <0.05
     COX-2 0.007 ± 0.005 0 ± 0 <0.05
     TIMP-1 35.3 ± 4.6 8.4 ± 5.4 <0.05
     MMP 3 2.428 ± 1.272 0.587 ± 0.18 <0.05
     ADAMTS 5 0.132 ± 0.05 0.024 ± 0.024 <0.05
p value ACL-X Control CaMTP CaLTP ACL-X Control p value
<0.05 378.6 ± 321.42 9.05 ± 7.08 COL 1 COL 1 78.85 ± 43.79 1.98 ± 1.72 <0.05
<0.05 2787 ± 1919 594 ± 151 COL 2 COL 2 1926 ± 939 708 ± 49 <0.05
<0.05 0.074 ± 0.059 0.007 ± 0.007 MMP 13 MMP 13 0.05 ± 0.002 0.011 ± 0.011 <0.05
<0.05 0.051 ± 0.044 0.003 ± 0.001 COX-2 COX-2 0.019 ± 0.006 0.002 ± 0.002 <0.05
<0.05 0.189 ± 0.019 0.088 ± 0.002 INOS     
<0.05 0.023 ± 0.011 0.002 ± 0.002 ADAMTS 5     
<0.05 1.4 ± 0.07 3.71 ± 0.08 TIMP-2 TIMP-2 0.99 ± 0.02 2.7 ± 0.8 <0.05
  1. Differentially expressed genes in the ACL-transected knee by region in the tibial plateau compared to the contralateral normal control. All genes listed were up regulated in the ACL-transected stifle except TIMP-2, which was down regulated in the ACL-transected stifle. Values listed are the mean relative level of expression (± standard error) for each gene compared to the house keeping gene GAPDH. Significant differences were determined using REST-XL, and relative expression levels were determined using Q-Gene.