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Table 2 Differentially expressed genes in the ACL-X knee by region in the femoral chondyle

From: Site-specific analysis of gene expression in early osteoarthritis using the Pond-Nuki model in dogs

p value ACL-X Control CrMFC CrLFC ACL-X Control p value
<0.05 11.1 ± 1.71 0.57 ± 0.27 COL 1 MMP 13 0.096 ± 0.061 0.006 ± 0.002 <0.05
<0.05 859 ± 229 298 ± 212 Aggrecan COX-2 0.017 ± 0.012 0.001 ± 0.001 <0.05
<0.05 0.075 ± 0.032 0 ± 0 MMP 13     
<0.05 0.106 ± 0.092 0.001 ± 0.001 COX-2     
<0.05 50.8 ± 18.8 16.8 ± 11.9 TIMP-1     
<0.05 10.4 ± 6.8 0.744 ± 0.224 MMP 3     
0.0555 0.853 ± 0.714 0.01 ± 0.006 ADAMTS 5     
p value ACL-X Control CaMFC CaLFC ACL-X Control p value
<0.05 709 ± 659 4.32 ± 0.35 COL 1 Aggrecan 370 ± 262 98 ± 23 <0.05
<0.05 1.224 ± 1.189 0.006 ± 0.001 MMP 13     
<0.05 0.009 ± 0.005 0.001 ± 0.001 COX-2     
<0.05 0.055 ± 0.028 0.016 ± 0.013 ADAMTS 5     
  1. Differentially expressed genes in the ACL-X knee by region in the femoral chondyle compared to the contralateral normal control. All genes listed were up regulated in the ACL-transected side. Values listed are the mean relative level of expression for each gene (± standard error) compared to the house keeping gene GAPDH. The increase in ADAMTS 5 gene expression in the CrMFC approached significance and was included in the table. Significant differences were determined using REST-XL, and relative expression levels were determined using Q-Gene.