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Table 2 Differentially expressed genes in the ACL-X knee by region in the femoral chondyle

From: Site-specific analysis of gene expression in early osteoarthritis using the Pond-Nuki model in dogs

p value

ACL-X

Control

CrMFC

CrLFC

ACL-X

Control

p value

<0.05

11.1 ± 1.71

0.57 ± 0.27

COL 1

MMP 13

0.096 ± 0.061

0.006 ± 0.002

<0.05

<0.05

859 ± 229

298 ± 212

Aggrecan

COX-2

0.017 ± 0.012

0.001 ± 0.001

<0.05

<0.05

0.075 ± 0.032

0 ± 0

MMP 13

    

<0.05

0.106 ± 0.092

0.001 ± 0.001

COX-2

    

<0.05

50.8 ± 18.8

16.8 ± 11.9

TIMP-1

    

<0.05

10.4 ± 6.8

0.744 ± 0.224

MMP 3

    

0.0555

0.853 ± 0.714

0.01 ± 0.006

ADAMTS 5

    

p value

ACL-X

Control

CaMFC

CaLFC

ACL-X

Control

p value

<0.05

709 ± 659

4.32 ± 0.35

COL 1

Aggrecan

370 ± 262

98 ± 23

<0.05

<0.05

1.224 ± 1.189

0.006 ± 0.001

MMP 13

    

<0.05

0.009 ± 0.005

0.001 ± 0.001

COX-2

    

<0.05

0.055 ± 0.028

0.016 ± 0.013

ADAMTS 5

    
  1. Differentially expressed genes in the ACL-X knee by region in the femoral chondyle compared to the contralateral normal control. All genes listed were up regulated in the ACL-transected side. Values listed are the mean relative level of expression for each gene (± standard error) compared to the house keeping gene GAPDH. The increase in ADAMTS 5 gene expression in the CrMFC approached significance and was included in the table. Significant differences were determined using REST-XL, and relative expression levels were determined using Q-Gene.