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  1. Research article

    Safety of three different product doses in autologous chondrocyte implantation: results of a prospective, randomised, controlled trial

    This study was conducted to assess the efficacy and safety of the three dose levels of the three-dimensional autologous chondrocyte implantation product chondrosphere® in the treatment of cartilage defects (4–...

    Christoph Becher, Volker Laute, Stefan Fickert, Wolfgang Zinser, Philipp Niemeyer, Thilo John, Peter Diehl, Thomas Kolombe, Rainer Siebold and Jakob Fay

    Journal of Orthopaedic Surgery and Research 2017 12:71

    Published on: 12 May 2017

  2. Research article

    A survey of proteomic biomarkers for heterotopic ossification in blood serum

    Heterotopic ossification (HO) is a significant problem for wounded warriors surviving high-energy blast injuries; however, currently, there is no biomarker panel capable of globally characterizing, diagnosing,...

    Laura E. Edsberg, Erin L. Crowgey, Patrick M. Osborn and Jennifer T. Wyffels

    Journal of Orthopaedic Surgery and Research 2017 12:69

    Published on: 4 May 2017

  3. Research article

    Prospective clinical and radiographic evaluation of an allogeneic bone matrix containing stem cells (Trinity Evolution® Viable Cellular Bone Matrix) in patients undergoing two-level anterior cervical discectomy and fusion

    Trinity Evolution® (TE), a viable cellular bone allograft, previously demonstrated high fusion rates and no safety-related concerns after single-level anterior cervical discectomy and fusion (ACDF) procedures....

    Timothy A. Peppers, Dennis E. Bullard, Jed S. Vanichkachorn, Scott K. Stanley, Paul M. Arnold, Erik I. Waldorff, Rebekah Hahn, Brent L. Atkinson, James T. Ryaby and Raymond J. Linovitz

    Journal of Orthopaedic Surgery and Research 2017 12:67

    Published on: 26 April 2017

  4. Research article

    Expression of calcitonin gene-related peptide in the infrapatellar fat pad in knee osteoarthritis patients

    The infrapatellar fat pad (IPFP) has been implicated as a possible source of osteoarthritis (OA) development and knee pain due to the production of inflammatory mediators and the existence of nerve fibers with...

    Jun Aikawa, Kentaro Uchida, Shotaro Takano, Gen Inoue, Atsushi Minatani, Masayuki Miyagi, Dai Iwase, Hiroyuki Sekiguchi, Manabu Mukai and Masashi Takaso

    Journal of Orthopaedic Surgery and Research 2017 12:65

    Published on: 21 April 2017

  5. Research article

    The evaluation of the role of medial collateral ligament maintaining knee stability by a finite element analysis

    A three-dimensional finite element model (FEM) of the knee joint was established to analyze the biomechanical functions of the superficial and deep medial collateral ligaments (MCLs) of knee joints and to inve...

    Dong Ren, Yueju Liu, Xianchao Zhang, Zhaohui Song, Jian Lu and Pengcheng Wang

    Journal of Orthopaedic Surgery and Research 2017 12:64

    Published on: 21 April 2017

  6. Retraction Note

    Journal of Orthopaedic Surgery and Research 2017 12:62

    Published on: 20 April 2017

    The original article was published in Journal of Orthopaedic Surgery and Research 2015 10:183

  7. Research article

    Shoulder ultrasonography performed by orthopedic surgeons increases efficiency in diagnosis of rotator cuff tears

    Rotator cuff tears are very common and their incidence increases with age. Shoulder ultrasonography has recently gained popularity in detecting rotator cuff tears because of its efficiency, cost-effectiveness,...

    Chih-Hao Chiu, Poyu Chen, Alvin Chao-Yu Chen, Kuo-Yao Hsu, Shih-Sheng Chang, Yi-Sheng Chan and Yeung-Jen Chen

    Journal of Orthopaedic Surgery and Research 2017 12:63

    Published on: 20 April 2017

  8. Review

    Injuries in extreme sports

    Extreme sports (ES) are usually pursued in remote locations with little or no access to medical care with the athlete competing against oneself or the forces of nature. They involve high ...

    Lior Laver, Ioannis P. Pengas and Omer Mei-Dan

    Journal of Orthopaedic Surgery and Research 2017 12:59

    Published on: 18 April 2017

  9. Research article

    Is combined use of intravenous and intraarticular tranexamic acid superior to intravenous or intraarticular tranexamic acid alone in total knee arthroplasty? A meta-analysis of randomized controlled trials

    Tranexamic acid (TXA) has been proven to be effective in reducing blood loss and transfusion rate after total knee arthroplasty (TKA) without increasing the risk of deep vein thrombosis (DVT) and pulmonary emb...

    Bobin Mi, Guohui Liu, Huijuan Lv, Yi Liu, Kun Zha, Qipeng Wu and Jing Liu

    Journal of Orthopaedic Surgery and Research 2017 12:61

    Published on: 18 April 2017

  10. Research article

    Acceleration of tendon–bone healing of anterior cruciate ligament graft using intermittent negative pressure in rabbits

    The purpose of this study was to test effects of negative pressure on tendon–bone healing after reconstruction of anterior cruciate ligament (ACL) in rabbits.

    Zhengming Sun, Xiaoqing Wang, Ming Ling, Wei Wang, Yanhai Chang, Guang Yang, Xianghui Dong, Shixun Wu, Xueyuan Wu, Bo Yang and Ming Chen

    Journal of Orthopaedic Surgery and Research 2017 12:60

    Published on: 18 April 2017

  11. Research article

    Impact of the body mass index on perioperative immunological disturbances in patients with hip and knee arthroplasty

    Obesity increases the risk for knee and hip joint implantation and negatively contributes to wound healing. In this study, in 52 patients undergoing hip and knee arthroplasty the amount of peripheral immune ef...

    Simon Jasinski-Bergner, Anna-Luise Radetzki, Janine Jahn, David Wohlrab and Heike Kielstein

    Journal of Orthopaedic Surgery and Research 2017 12:58

    Published on: 8 April 2017

  12. Research article

    The therapeutic characteristics of serial casting on congenital scoliosis: a comparison with non-congenital cases from a single-center experience

    The therapeutic efficacy of serial casting on idiopathic scoliosis has been gradually documented. However, literatures on serial casting for congenital scoliosis (CS) remain extremely rare. This paper aimed to...

    Jun Cao, Xue-jun Zhang, Ning Sun, Lin Sun, Dong Guo, Xin-yu Qi, Yun-song Bai and Bao-sheng Sun

    Journal of Orthopaedic Surgery and Research 2017 12:56

    Published on: 4 April 2017

  13. Research article

    All-polyethylene tibial components in distal femur limb-salvage surgery: a finite element analysis based on promising clinical outcomes

    Whether all-polyethylene tibial (APT) components are beneficial to patients who received distal femur limb-salvage surgery lacks high-quality clinical follow-up and mechanical evidence. This study aimed to inv...

    Fan Tang, Yong Zhou, Wenli Zhang, Li Min, Rui Shi, Yi Luo, Hong Duan and Chongqi Tu

    Journal of Orthopaedic Surgery and Research 2017 12:57

    Published on: 4 April 2017

  14. Research article

    Incidence of venous thromboembolism and bleeding events in patients with lower extremity orthopedic surgery: a retrospective analysis of a Japanese healthcare database

    Orthopedic surgeries of lower extremities such as total knee arthroplasty (TKA), total hip arthroplasty (THA), and hip fracture surgery (HFS) are widely considered to carry a high risk of developing deep venou...

    Takeshi Fuji, Masao Akagi, Yasuyuki Abe, Eisei Oda, Daisuke Matsubayashi, Kaori Ota, Masafumi Kobayashi, Yasuyuki Matsushita, Jumpei Kaburagi, Kei Ibusuki, Atsushi Takita, Mikio Iwashita and Takuhiro Yamaguchi

    Journal of Orthopaedic Surgery and Research 2017 12:55

    Published on: 4 April 2017

  15. Research article

    Novel intramedullary device for lengthening transfemoral residual limbs

    Lower limb loss is a highly disabling medical condition that can severely impact a person’s quality of life. Recovery becomes especially challenging if an amputee has a short residual limb, which can complicat...

    Todd A. Kuiken, Bennet A. Butler, Tom Sharkey, Andre D. Ivy, Daniel Li and Terrance D. Peabody

    Journal of Orthopaedic Surgery and Research 2017 12:53

    Published on: 31 March 2017

  16. Research article

    Effectiveness of multi-drug regimen chemotherapy treatment in osteosarcoma patients: a network meta-analysis of randomized controlled trials

    Osteosarcoma is the most common malignant bone tumour. Due to the high metastasis rate and drug resistance of this disease, multi-drug regimens are necessary to control tumour cells at various stages of the ce...

    Xiaojie Wang, Hong Zheng, Tao Shou, Chunming Tang, Kun Miao and Ping Wang

    Journal of Orthopaedic Surgery and Research 2017 12:52

    Published on: 29 March 2017

  17. Research article

    MiRNA expression in the cartilage of patients with osteoarthritis

    Osteoarthritis (OA), the most prevalent disease of articulating joints, is a complex multifactorial disease caused by genetic, mechanical, and environmental factors. In this research, we evaluated miRNA expres...

    Marta Kopańska, Dariusz Szala, Joanna Czech, Natalia Gabło, Krzysztof Gargasz, Mateusz Trzeciak, Izabela Zawlik and Sławomir Snela

    Journal of Orthopaedic Surgery and Research 2017 12:51

    Published on: 28 March 2017

    The Erratum to this article has been published in Journal of Orthopaedic Surgery and Research 2017 12:90

  18. Research article

    Unicompartmental knee arthroplasty, is it superior to high tibial osteotomy in treating unicompartmental osteoarthritis? A meta-analysis and systemic review

    Debate remains whether high tibial osteotomy (HTO) or unicompartmental knee arthroplasty (UKA) is more beneficial for the treatment of unicompartmental knee osteoarthritis. The purpose of this study was to com...

    Marcel Budhi Santoso and Lidong Wu

    Journal of Orthopaedic Surgery and Research 2017 12:50

    Published on: 28 March 2017

  19. Review

    The efficacy of pregabalin for the management of postoperative pain in primary total knee and hip arthroplasty: a meta-analysis

    A systematic review of randomized controlled trials (RCTs) was conducted to evaluate the efficacy of pregabalin for the management of postoperative pain in patients undergoing primary total knee arthroplasty (...

    Fei Li, Jianxiong Ma, Mingjie Kuang, Xuan Jiang, Ying Wang, Bin Lu, Xingwen Zhao, Lei Sun and Xinlong Ma

    Journal of Orthopaedic Surgery and Research 2017 12:49

    Published on: 24 March 2017

  20. Research article

    Patient compliance with touchdown weight bearing after microfracture treatment of talar osteochondral lesions

    The aim of this study was to prospectively evaluate the compliance of our patients with a touchdown weight bearing (without supporting any weight on the affected side by only touching the plantar aspect of the...

    Gökhan Polat, Gökhan Karademir, Ekin Akalan, Mehmet Aşık and Mehmet Erdil

    Journal of Orthopaedic Surgery and Research 2017 12:46

    Published on: 20 March 2017

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