Diagnostic challenge: bilateral infected lumbar facet cysts - a rare cause of acute lumbar spinal stenosis and back pain
© Freedman et al; licensee BioMed Central Ltd. 2010
Received: 18 July 2009
Accepted: 5 March 2010
Published: 5 March 2010
Symptomatic synovial lumbar facet cysts are a relatively rare cause of radiculopathy and spinal stenosis. This case and brief review of the literature, details a patient who presented with acutely symptomatic bilateral spontaneously infected synovial facet (L4/5) cysts. This report highlights diagnostic clues for identifying infection of a facet cyst.
Lumbar facet cysts are a less common but well documented cause of compressive radiculopathy and lumbar spinal stenosis, with approximately 500 total cases reported in the literature [1–5]. The lumbar facet is a synovial-lined zygoaphophyseal joint, comprising the articulation between the inferior and superior articulating processes of the spinal vertebrae. The facet joint, like synovial lined joints of the appendicular skeleton, are prone to cyst formation as a manifestation of osteoarthritis. To date, infection of a lumbar facet cyst has not been reported in the literature. This case illustrates the clinical findings and outcomes associated with bilateral infected lumbar facet cysts.
Our patient is a 63 year old overweight gentleman who presented to the emergency room with a three day history of progressive low back pain and pain radiating down the right worse than left leg in an L5 distribution. He also noted an acute onset of drop foot. He rated his pain as 10 out of 10. He reported that he has had a history of intermittent back pain, but no prior leg symptoms. He has diabetes, which was marginally controlled (HgbA1C was 7.4), coronary artery disease and one week prior to presentation he completed an 8 week course of radiation therapy for prostate cancer.
On examination, he was in significant pain. He had bilateral lower extremity weakness. His motor strength testing revealed 4/5 left and right iliopsoas and 4+/5 left and right quadriceps, hamstrings and gastrocnemius muscles, all of which appeared to be pain induced reductions of strength. Additionally, he had 3/5 left and right tibialis anterior (TA) and extensor hallucis longus (EHL) function. His peroneals were also weak (4-/5). He had normal sensation to light touch and pin prick. His deep tendon reflexes were 2+ bilaterally. He had a normal upper extremity neurological and digital rectal exam.
Imaging and Labs
Pertinent lab values.
8 week follow-up
.27 (0.033 at 3mo)
Operation and Pathological Findings
The clinical exam, imaging studies and laboratory findings all suggested this patient's symptoms were due to a L4/5 degenerative facet cyst causing symptomatic lumbar stenosis; however the markedly elevated CRP and ESR and inflammatory signal on MRI was worrisome for an infectious etiology. He was admitted to the hospital and taken to the OR the following day for a decompression and possible fusion of L4/5. Intraoperatively, exposing the L4/5 facets revealed voluminous cysts that expressed frank pus upon incision. As a result, we decided to stage this patient's surgeries. At the first stage we performed subtotal L4 and L5 laminectomies, near-total facet capsulectomy, partial facetectomy and thorough lavage to widely eradicate the infected structures. The infection appeared to be completely contained within the facet cysts. Tissue samples were sent for culture and pathology, which grew out Methicillin-Resistant Staphylococcus Aureus (MRSA). Pathology showed chronic and acute inflammatory changes without evidence of neoplasm. Infectious disease was consulted and he was started on intravenous Vancomycin, which was continued for a total of 6 weeks. Two days following the initial procedure, he underwent a direct lateral interbody fusion (X-LIF, NuVasive, Inc, San Diego, CA) with BMP-2 (InFuse, Medtronic, Inc, Minneapolis, MN) and posterior pedicle screw instrumentation.
After his decompression surgery, the patient did well, with cessation of radicular symptoms, and was discharged on the 4th postoperative day following the subsequent X-LIF. Upon discharge from the hospital, his pain level improved to 5/10, with pain solely in his back. His motor strength normalized in all groups except for EHL, TA and P, which only improved to 4/5. However, this was sufficient to eliminate his drop foot gait. At his 2 week clinic appointment, he was afebrile and his wound was healing without complication.
Unfortunately, our patient was a visitor to this country who permanently resided in the Virgin Islands. He had been here for his cancer treatments, but upon resolution of his back and leg symptoms, he returned to his home. He was scheduled to return to our clinic 2 weeks, 6 weeks, and 3 and 6 months postoperatively, but only came for a 2 and 8 week visit. At his 8 week visit, he had completed his IV antibiotic therapy two weeks prior and denied any pain. He rated pain in his legs and back as 0/10. He still had some slight L5 weakness (4+/5 EHL, TA) on examination; however, this did not affect his gait. His laboratory values had normalized. (Table 1) Due to his living situation, follow-up at 3 and 6 months was obtained telephonically and demonstrated no evidence of recurrent leg symptoms or infection.
The clinical presentation, management and outcomes of aseptic lumbar facet cysts have been reported [1–6]. In 2004, Epstein performed a comprehensive review of the 15 published case series, which provides defining characteristics of this pathology. Facet cysts are detected in 0.6 - 10% of MRI scans of the lumbar spine [1–7]. The L4/5 level is most commonly affected and cysts most commonly occur in patients 60-65 years of age[1–3, 5, 8]. L5 radiculopathy is the most common primary complaint, although 95-100% of patients will have low back pain, as well[1, 2, 9].
Facet sagittal orientation (> 45 degrees) and facet arthrosis are present in over 77% of patients with symptomatic lumbar facet cysts [9–11]. As in the appendicular skeleton, the primary response of synovial joints to arthritis, is the over-production of synovial fluid, which in turn raises the intra-capsular pressure. In some patients, weak or thin areas in the facet capsule give way, the result is a focal mushroom-like swelling[1, 12]. With time cystic fluid dehydrates, and the cyst itself undergoes myxoid degeneration. Classic cystic appearance on MRI (isodense and isointense with CSF) occurs in as few as 57% of facet cysts. These space occupying lesions can compress nerve roots, causing radiculopathy (57-75%) or neurogenic claudication (25%)[2, 9, 13].
Although cases of successful nonoperative treatment have been reported with steroid injections or image-guided aspiration, for the most part, symptomatic synovial cysts require excision[1, 2, 9, 14]. While agreement exists for surgical intervention of symptomatic facet cysts, the extent of surgery needed is debatable. Surgeons tend to favor either decompression alone or decompression and fusion, with decompression alone being the more commonly reported approach[1, 5]. Concurrent spondylolisthesis, especially in the presence of significant low back pain, is the most common reason for adding an arthrodesis[1, 3, 5, 12]. The lack of prospective cohort studies require surgeons to base their treatment plan on hypothesis and interpretation of case series which report good-excellent results (in > 75% of cases) for both approaches[1, 5, 12]. Those who advocate arthrodesis tend to point to two primary issues. First, the cyst is only an effect, the true cause is the underlying facet arthrosis and possibly instability[3, 12]. Simply excising the cyst will not treat the cause. Conversely, the rate of recurrence following laminectomy alone appears to be quite low, averaging < 3% across published series[1, 13]. Second, patients with lumbar facet cysts overwhelmingly have abnormal motion segments and low back pain[2, 3, 9, 12]. Excision and decompression alone does not address these concomitant pathologies and may worsen segmental instability[3, 9]. However, the rate of re-operation for symptomatic instability appears to be low as well (2% in Lyons et al. series of 194 patients).
Our patient had chronic low back pain, sagittally oriented facets (> 45 degrees) with extensive cystic and sclerotic changes. We performed significant facetectomies and near-total capsulectomy to widely debride the infection; thus we elected to fuse his spine. His recent XRT exposure and his underlying marginally controlled diabetes made him vulnerable to infection--Class B host. Hypertrophic synovium in facet cysts, devoid of a basement membrane, allowed MRSA to localize and develop into a closed space infection. This sequence of hematogenous seeding and subsequent infection is common to other synovial joints. This case clearly demonstrates that this can occur in lumbar facet joints, as well. Further, debridement of the infected tissue, prolonged culture-specific antibiotic and stabilization through instrumented spinal fusion can successfully eradicate this rare form of infection and result in an excellent clinical outcome (= complete symptom resolution, no recurrence)[1, 12].
This case report highlights diagnostic clues that suggest infection of an underlying facet cyst. The key findings appear to be rapid progression of symptoms, associated elevation in CRP and ESR and paravertebral muscles edema. Symptomatic neurological compression in uncomplicated facet cysts develops over time as degeneration progresses. Only 7% of cases present within 7 days of symptom onset, perhaps dues to intra-cystic hemorrhage[1, 9, 17]. In patients presenting with acutely progressive lumbar stenotic or radiculopathic symptoms which are attributed to lumbar facet cysts, the possibility of infection of the cysts should be considered and evaluated.
Written informed consent to publish could not be obtained despite reasonable attempts. The patient cannot be identified from the case report and there is no reason to believe that they would object to its publication.
We would like to acknowledge Bettie Cheek, RN for her assistance with this project.
No funding was received in support of this project.
- Boviatsis EJ, Staurinou LC, Kouyialis AT, Gavra MM, Stavrinou PC, Themistokleous M, Selviaridis P, Sakas DE: Spinal synovial cysts: pathogenesis, diagnosis and surgical treatment in a series of seven cases and literature review. Eur Spine J. 2008, 17 (6): 831-7. 10.1007/s00586-007-0563-z.PubMed CentralView ArticlePubMedGoogle Scholar
- Epstein NE: Lumbar Synovial Cysts. A Review of Diagnosis, Surgical Management and Outcome Assessment. J Spinal Disord Tech. 2004, 17: 321-325. 10.1097/01.bsd.0000096267.75190.eb.View ArticlePubMedGoogle Scholar
- Epstein NE: Lumbar laminectomy for the resection of synovial cysts and coexisting lumbar spinal stenosis or degenerative spondylolisthesis: an outcome study. Spine. 2004, 29 (9): 1049-55. 10.1097/00007632-200405010-00018.View ArticlePubMedGoogle Scholar
- Eyster EF, Scott WR: Lumbar synovial cysts: report of eleven cases. Neurosurgery. 1989, 24: 112-115. 10.1097/00006123-198901000-00021.View ArticlePubMedGoogle Scholar
- Lyons MK, Atkinson JL, Wharen RE, Deen HG, Zimmerman RS, Lemens SM: Surgical evaluation and management of lumbar synovial cysts: the Mayo Clinic experience. J Neurosurg. 2000, 93 (suppl 1): 53-57.PubMedGoogle Scholar
- Banning CS, Thorell WE, Leibrock LG: Patient outcome after resection of lumbarjuxtafacet cysts. Spine. 2001, 26: 969-972. 10.1097/00007632-200104150-00024.View ArticlePubMedGoogle Scholar
- Doyle AJ, Merrilees M: Synovial cysts of the lumbar facet joints in a symptomatic population: prevalence on magnetic resonance imaging. Spine. 2004, 29: 874-878. 10.1097/00007632-200404150-00010.View ArticlePubMedGoogle Scholar
- Deinsberger R, Kinn E, Ungersböck K: Microsurgical treatment of juxta facet cysts of the lumbar spine. J Spinal Disord Tech. 2006, 19 (3): 155-60. 10.1097/01.bsd.0000188660.31212.83.View ArticlePubMedGoogle Scholar
- Metellus P, Fuentes S, Adetchessi T, Levrier O, Flores-Parra I, Talianu D, Dufour H, Bouvier C, Manera L, Grisoli F: Retrospective study of 77 patients harbouring lumbar synovial cysts: functional and neurological outcome. Acta Neurochir (Wien). 2006, 148: 47-54. 10.1007/s00701-005-0650-z.View ArticleGoogle Scholar
- Fujiwara A, Tamai K, An HS, Lim TH, Yoshida H, Kurihashi A, Saotome K: Orientation and osteoarthritis of the lumbar facet joint. Clin Orthop Relat Res. 2001, 88-94. 10.1097/00003086-200104000-00015. 385
- Fujiwara A, Tamai K, An HS, Kurihashi T, Lim TH, Yoshida H, Saotome K: The relationship between disc degeneration, facet joint osteoarthritis, and stability of the degenerative lumbar spine. J Spinal Disord. 2000, 13 (5): 444-50. 10.1097/00002517-200010000-00013.View ArticlePubMedGoogle Scholar
- Khan AM, Synnot K, Cammisa FP, Girardi FP: Lumbar synovial cysts of the spine: an evaluation of surgical outcome. J Spinal Disord Tech. 2005, 18 (2): 127-31. 10.1097/01.bsd.0000156830.68431.70.View ArticlePubMedGoogle Scholar
- Howington JU, Connolly ES, Voorhies RM: Intraspinal synovial cysts: 10-year experience at the Ochsner Clinic. J Neurosurg. 1999, 91 (2 Suppl): 193-9.PubMedGoogle Scholar
- Parlier-Cuau C, Wybier M, Nizard R, Champsaur P, Le Hir P, Laredo JD: Symptomatic lumbar facet joint synovial cysts: clinical assessment of facet joint steroid injection after 1 and 6 months and long term follow-up in 30 patients. Radiology. 1999, 210: 509-513.View ArticlePubMedGoogle Scholar
- Cierny G, Mader JT: Approach to adult osteomyelitis. Orthop Rev. 1987, 16 (4): 259-70.PubMedGoogle Scholar
- Zink BJ, Weber JE: Chapter 130 - Bone and Joint Infections. Rosen's Emergency Medicine: Concepts and Clinical Practice. Edited by: Marx JA. 2002, St Louis, MO: Mosby, Inc, 1925-43. 5Google Scholar
- Ramieri A, Domenicucci M, Seferi A, Paolini S, Petrozza V, Delfini R: Lumbar hemorrhagic synovial cysts: diagnosis, pathogenesis, and treatment. Report of 3 cases. Surg Neurol. 2006, 65: 385-390. 10.1016/j.surneu.2005.07.073.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.